Which side effect should the nurse inform a client about when taking amoxapine (Ascendin) for major depression?

When taking amoxapine, it is important for the nurse to inform the client about dry mouth as a potential side effect. Amoxapine, which is a tricyclic antidepressant, commonly causes anticholinergic effects, one of which is dry mouth. This occurs due to the medication’s action in blocking acetylcholine receptors, which can lead to decreased saliva production.

Understanding this side effect is crucial for clients, as dry mouth can lead to discomfort, difficulty swallowing, and an increased risk for dental issues if not managed properly. Clients may also be encouraged to stay hydrated, use saliva substitutes, or maintain good oral hygiene to alleviate this symptom.

While other side effects like nausea, weight gain, and insomnia are also possible, dry mouth is particularly noteworthy as it can significantly impact the client's comfort and adherence to the medication. Recognizing and addressing this side effect can enhance the client's overall experience while being treated for major depression.