What term describes the continued use of a substance despite significant related problems?

The term that describes the continued use of a substance despite significant related problems is termed "substance dependence." This condition implies not only a physical compulsion to use the substance but also psychological aspects where the individual continues to use it despite facing adverse consequences, such as health issues, relationship problems, or other detrimental effects on life quality.

Substance dependence often involves a higher tolerance, meaning the person needs more of the substance to achieve the same effects, and they may experience withdrawal symptoms when not using it. This differs from substance use disorder, which is a broader classification that encompasses a range of problematic behaviors and symptoms associated with substance use, including dependence.

While substance abuse generally refers to the harmful or hazardous use of the substance, it does not necessarily include the physical or psychological dependence aspect that defines substance dependence. Additionally, substance withdrawal describes the physical and mental symptoms that occur after stopping or reducing intake of a substance after prolonged use, but it does not encompass the continuity of use in the face of problems. Therefore, substance dependence accurately captures the relationship between continued usage and the significant problems that arise from it.