What mediates the release of endorphins?

The correct answer is serotonin, which plays a crucial role in mediating the release of endorphins. Serotonin is a neurotransmitter that significantly influences mood, emotion, and social behavior, but it also affects various physiological functions. When serotonin levels are elevated, such as during activities like exercise or in response to pain relief, it can stimulate the release of endorphins.

Endorphins are known as the body’s natural painkillers and are involved in promoting feelings of pleasure and satisfaction. The presence of serotonin facilitates the neuronal pathways that enable the release of these endorphins, contributing to the feelings of euphoria often referred to as the "runner's high."

Considering the other options: adrenaline is primarily involved in the body's fight-or-flight response and is not directly responsible for endorphin release. Dopamine is linked to reward and pleasure pathways but does not directly mediate endorphin release. Endocannabinoids, while involved in regulating various physiological processes, do not serve as a primary mediator for endorphin release like serotonin does.